Penelitian
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Publikasi ilmiah adalah salah satu komponen penting dalam pendidikan tinggi. Dosen dan mahasiswa khususnya di tingkat doktoral sebagai peneliti dituntut untuk memiliki publikasi di jurnal internasional sebagai salah satu hasil dari penelitian yang telah dilakukan. Tidak hanya sembarang jurnal, kita dituntut mempublikasi hasil penelitian di jurnal terindeks, termasuk di Program Studi Doktor FK-KMK UGM mensyaratkan bagi mahasiswa doktoral untuk publikasi jurnal minimum pada Quartile 3 (Q3).
Saat ini ribuan jurnal diterbitkan di seluruh dunia. Namun, tidak sedikit jurnal-jurnal predator yang menawarkan proses submisi yang mudah dan cepat namun tidak bisa dipertanggungjawabkan kualitasnya. Hal ini perlu diwaspadai agar artikel dapat dipublikasikan di jurnal terindeks dan terjamin kualitasnya.
Kementerian Pendidikan dan Kebudayaan melalui Dikti telah mengidentifikasi jurnal-jurnal yang harus dihindari sebab dipertanyakan kredibilitasnya. Daftar dapat diakses melalui tautan berikut: Link
Tautan daftar lengkap Discontinued Sources List Scopus Edisi Desember 2025: Link
Pemilihan jurnal memerlukan pertimbangan dari aspek kualitas jurnal. Bagi mahasiswa yang submit manuskrip ke jurnal yang diskontinyu Scopus setelah bulan Desember 2025 dan manuskripnya kemudian accepted atau terpublikasi, maka manuskrip tersebut tidak dapat digunakan sebagai syarat untuk ujian tertutup.
Publikasi Mahasiswa dan Alumni Prodi Doktor FKKMK UGM
What Do Seniors Belive About Medication Adherence? A Qualitative Study Among Seniors with Chronic Conditions in Yogyakarta, Indonesia
Equipping pharmacists for delivering pharmaceutical care to seniors: a qualitative systematic review of Asian seniors’ social support
The Role of HMGB1 in COVID-19-induced cytokine strom and its potential therautic targets: A review
Secular trends in Javanese adult height: the roles of environment and educational attainment
The interactional communication of feedback in clinical education: A focused ethnographic study in a hierarchical and collectivist culture
Screening antibiofilm activity of invasive plants growing at the Slope Merapi Mountain, Central Java, against Candida albicans
Abstract
Background Candida albicans causes high-mortality candidiasis. Antifungal drug resistance demands the devel- opment of virulence factor-targeting drugs, particularly antibiofilm. This study screened the effects of five invasive plants growing in Indonesia (Mimosa pudica, Lantana camara, Acacia mangium, Ageratina riparia, and Mikania micran- tha) against C. albicans biofilms. Antifungal activity, antiphospholipase activity, biofilm morphology of C. albicans, and cytotoxic capacity were also evaluated.
Methods Maceration was used to extract the plants, and the most active extract inhibiting the biofilms was fraction- ated using liquid–liquid fractionation. Antibiofilm activity was determined by a colorimetric assay, MTT. Antifungal activity was tested using the broth microdilution method. A phospholipase assay was performed using the egg-yolk agar method. Influence on the C. albicans morphology was assessed using scanning electron microscopy (SEM).
The cytotoxic effect was carried out against Vero and HeLa cell lines.
Results M. pudica extracts showed the most potent antifungal efficacy with minimum inhibitory concentration (MIC) of 15.62 µg/mL and 7.81 µg/mL for aerial parts and roots, respectively. At high concentrations (500 µg/mL and 250 µg/mL), ethanol extract of M. pudica aerial parts strongly inhibited the phospholipase activity. Ethyl-acetate fraction of M. pudica aerial parts demonstrated the most potent antibiofilm activity against 24 h old biofilm of C. albicans with an inhibitory concentration (53.89%) of 62.5 µg/mL showed no cytotoxicity in both Vero and HeLa cells. This fraction affected the morphology of C. albicans and contained promising compounds for inhibiting the 24 h old biofilm of C. albicans.
Conclusions Invasive M. pudica plant inhibited the growth of planktonic C. albicans cells and its ethyl acetate fraction decreased the metabolic activity of C. albicans biofilms. This result demonstrates the potential of invasive M. pudica plant to reduce biofilm-associated candida infection.
Keywords Invasive plants, Candida albicans, Antifungal, Antibiofilm, Mimosa pudica